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DC Field | Value | Language |
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dc.contributor.author | Chua, M. J. | - |
dc.contributor.author | Varshney, N. | - |
dc.contributor.author | Eke, T. | - |
dc.date.accessioned | 2024-03-11T01:57:35Z | - |
dc.date.available | 2024-03-11T01:57:35Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 08863350 (ISSN) | - |
dc.identifier.uri | https://swslhd.intersearch.com.au/swslhdjspui/handle/1/12619 | - |
dc.description.abstract | Phenylephrine, a potent sympathomimetic, induces mydriasis via iris dilator muscle contraction. Intracameral (IC) phenylephrine has been successfully used in cataract surgery for initial mydriasis, maintaining mydriasis, and management of intraoperative floppy-iris syndrome. Serious systemic adverse events (mainly cardiovascular) have been described with topical phenylephrine drops, but we found very little evidence of such adverse events associated with IC phenylephrine use. However, we suspect under-reporting of such adverse events, as they may instead be ascribed to anxiety, positioning, anesthesia, etc. Optimal dosage/concentrations for IC phenylephrine use in different purposes have not been fully studied. In the absence of robust evidence, we suggest that lower but effective IC phenylephrine concentrations are used: a lower concentration (0.31%), in conjunction with an anticholinergic and lidocaine, may be used for initial mydriasis. For management of intraoperative floppy-iris syndrome, 0.31% may be effective, though a higher concentration (1% to 1.25%) may be required. Copyright � 2023 The Author(s). | - |
dc.publisher | Lippincott Williams and Wilkins | - |
dc.subject | Humans Iatrogenic Disease Intraoperative Complications Iris Iris Diseases Mydriasis Mydriatics Phacoemulsification Phenylephrine Pupil cholinergic receptor blocking agent lidocaine mydriatic agent cataract extraction comparative study dehydration diastolic blood pressure drug efficacy drug safety heart infarction heart rate human hypertension intraoperative floppy iris syndrome non insulin dependent diabetes mellitus operation duration optimal drug dose pericardial effusion randomized controlled trial (topic) respiratory arrest Review systolic blood pressure transient ischemic attack iris disease peroperative complication procedures | - |
dc.title | Intracameral phenylephrine for surgical mydriasis and intraoperative floppy-iris syndrome: systemic adverse effects and optimal dose | - |
dc.type | Journal Article | - |
dc.contributor.swslhdauthor | Chua, Matthew J. | - |
dc.description.affiliates | The Department of Anaesthesia, Liverpool Hospital, Liverpool, Australia East Kent Hospitals University NHS Foundation Trust, Canterbury, United Kingdom Department of Ophthalmology, Norfolk and Norwich University Hospital, Norwich, United Kingdom | - |
dc.identifier.doi | 10.1097/j.jcrs.0000000000001319 | - |
dc.identifier.department | Liverpool Hospital, Department of Anaesthesia | - |
dc.type.studyortrial | Review | - |
dc.identifier.journaltitle | Journal of Cataract and Refractive Surgery | - |
Appears in Collections: | Liverpool Hospital |
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