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DC Field | Value | Language |
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dc.contributor.author | Chin, V. | - |
dc.contributor.author | Chlap, P. | - |
dc.contributor.author | Finnegan, R. | - |
dc.contributor.author | Hau, E. | - |
dc.contributor.author | Ong, A. | - |
dc.contributor.author | Ma, X. | - |
dc.contributor.author | Descallar, J. | - |
dc.contributor.author | Otton, J. | - |
dc.contributor.author | Holloway, L. | - |
dc.contributor.author | Delaney, G. P. | - |
dc.contributor.author | Vinod, S. K. | - |
dc.date.accessioned | 2024-09-02T05:56:34Z | - |
dc.date.available | 2024-09-02T05:56:34Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 09366555 (ISSN) | - |
dc.identifier.uri | https://swslhd.intersearch.com.au/swslhdjspui/handle/1/12903 | - |
dc.description.abstract | Background and Purpose: Stereotactic ablative body radiotherapy (SABR) is increasingly used for early-stage lung cancer, however the impact of dose to the heart and cardiac substructures remains largely unknown. The study investigated doses received by cardiac substructures in SABR patients and impact on survival. Materials and Methods: SSBROC is an Australian multi-centre phase II prospective study of SABR for stage I non-small cell lung cancer. Patients were treated between 2013 and 2019 across 9 centres. In this secondary analysis of the dataset, a previously published and locally developed open-source hybrid deep learning cardiac substructure automatic segmentation tool was deployed on the planning CTs of 117 trial patients. Physical doses to 18 cardiac structures and EQD2 converted doses (?/? = 3) were calculated. Endpoints evaluated include pericardial effusion and overall survival. Associations between cardiac doses and survival were analysed with the Kaplan?Meier method and Cox proportional hazards models. Results: Cardiac structures that received the highest physical mean doses were superior vena cava (22.5 Gy) and sinoatrial node (18.3 Gy). The highest physical maximum dose was received by the heart (51.7 Gy) and right atrium (45.3 Gy). Three patients developed grade 2, and one grade 3 pericardial effusion. The cohort receiving higher than median mean heart dose (MHD) had poorer survival compared to those who received below median MHD (p = 0.00004). On multivariable Cox analysis, male gender and maximum dose to ascending aorta were significant for worse survival. Conclusions: Patients treated with lung SABR may receive high doses to cardiac substructures. Dichotomising the patients according to median mean heart dose showed a clear difference in survival. On multivariable analyses gender and dose to ascending aorta were significant for survival, however cardiac substructure dosimetry and outcomes should be further explored in larger studies. � 2024 The Author(s) | - |
dc.publisher | Elsevier Ltd | - |
dc.subject | Automatic segmentation Cardiac substructures Lung cancer Stereotactic radiotherapy Survival outcome | - |
dc.title | Cardiac Substructure Dose and Survival in Stereotactic Radiotherapy for Lung Cancer: Results of the Multi-Centre SSBROC Trial | - |
dc.type | Journal Article | - |
dc.contributor.swslhdauthor | Chin, Vicky | - |
dc.contributor.swslhdauthor | Chlap, Phillip | - |
dc.contributor.swslhdauthor | Otton, James M. | - |
dc.contributor.swslhdauthor | Holloway, Lois C. | - |
dc.contributor.swslhdauthor | Delaney, Geoff P. | - |
dc.contributor.swslhdauthor | Vinod, Shalini K. | - |
dc.description.affiliates | University of New South Wales, South Western Sydney Clinical School, Sydney, Australia Liverpool and Macarthur Cancer Therapy Centres, Department of Radiation Oncology, Sydney, Australia Ingham Institute for Applied Medical Research, Sydney, Australia University of Sydney, Image X Institute, Sydney, Australia Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia University of Sydney, Institute of Medical Physics, Sydney, Australia Crown Princess Mary Cancer Centre, Westmead Hospital, Department of Radiation Oncology, Sydney, Australia Blacktown Haematology and Cancer Centre, Blacktown Hospital, Department of Radiation Oncology, Sydney, Australia Westmead Institute of Medical Research, Centre for Cancer Research, Sydney, Australia University of Sydney, Westmead Clinical School, Sydney, Australia St George Hospital, Division of Cancer Services, Sydney, Australia Liverpool Hospital, Department of Cardiology, Sydney, Australia | - |
dc.identifier.doi | 10.1016/j.clon.2024.07.005 | - |
dc.identifier.department | Liverpool Hospital, Cancer Therapy Centre | - |
dc.identifier.department | Liverpool Hospital, Department of Cardiology | - |
dc.type.studyortrial | Article | - |
dc.identifier.journaltitle | Clinical Oncology | - |
Appears in Collections: | Liverpool Hospital |
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