Radiotherapy protocol compliance in routine clinical practice for patients with stages I?III non-small-cell lung cancer

Abstract

Introduction: Despite the availability of radiotherapy treatment protocols for�lung cancer, considerable treatment variation occurs in clinical practice. This study assessed compliance with a radiotherapy protocol for the treatment of patients with stages I?III non-small-cell lung cancer (NSCLC) in routine clinical practice and to identify factors that were associated with compliance. Methods: The Cancer Institute New South Wales eviQ treatment protocol for external beam radiotherapy of stages I?III NSCLC was taken as the reference to measure compliance. All inoperable patients with stages I?III NSCLC and documented ECOG performance status treated with radiotherapy between 2007 and 2019 at two radiotherapy facilities were available for analysis. Protocol compliance rates were calculated. Univariate and multivariate logistic regression models with 23 input factors were used to determine factors significantly associated with compliance. Survival analysis was conducted for both compliant and non-compliant treatments. Results: Overall, 656 patients met the inclusion criteria. Protocol compliance was 16%. Alternative dose/fractionation was responsible for 49% of non-compliant treatments with 30% receiving an alternative curative fractionation. Five of 23 factors (age at the start of radiotherapy, stage group, ECOG performance status, tumour location and alcoholism history) showed significant associations with protocol compliance on multivariate analysis. There was no significant difference in median survival between patients receiving protocol compliant treatment (15.1 months) and non-compliant treatment (15.6 months). Conclusion: Adherence to the eviQ curative radiotherapy protocol for stages I?III NSCLC was low. Alternative dose/fractionation schemes were the main reason for non-compliance. Protocol compliance was not associated with outcome. � 2024 The Royal Australian and New Zealand College of Radiologists.