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dc.contributor.author | Coutts, S. B. | - |
dc.contributor.author | Ankolekar, S. | - |
dc.contributor.author | Appireddy, R. | - |
dc.contributor.author | Arenillas, J. F. | - |
dc.contributor.author | Assis, Z. | - |
dc.contributor.author | Bailey, P. | - |
dc.contributor.author | Barber, P. A. | - |
dc.contributor.author | Bazan, R. | - |
dc.contributor.author | Buck, B. H. | - |
dc.contributor.author | Butcher, K. S. | - |
dc.contributor.author | Camden, M. C. | - |
dc.contributor.author | Vandervelde, C. | - |
dc.contributor.author | Ratnayake, K. | - |
dc.contributor.author | McMillan, S. | - |
dc.contributor.author | Katsanos, A. | - |
dc.contributor.author | Shoamanesh, A. | - |
dc.contributor.author | Hunter, G. | - |
dc.contributor.author | Sahlas, D. J. | - |
dc.contributor.author | Naidoo, V. | - |
dc.contributor.author | Todorov, V. | - |
dc.contributor.author | Moores, M. | - |
dc.contributor.author | Popel, N. | - |
dc.contributor.author | Toma, H. | - |
dc.contributor.author | Brar, J. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Horton, M. | - |
dc.contributor.author | Shand, E. | - |
dc.contributor.author | Weatherby, S. | - |
dc.contributor.author | Jin, A. | - |
dc.contributor.author | Imoukhuede, O. | - |
dc.contributor.author | Durafourt, B. | - |
dc.contributor.author | Jalini, S. | - |
dc.contributor.author | Norouzi, V. | - |
dc.contributor.author | Panzini, M. A. | - |
dc.contributor.author | Gardner, A. | - |
dc.contributor.author | Tyson, C. | - |
dc.contributor.author | Junk, E. | - |
dc.contributor.author | Foster, K. | - |
dc.contributor.author | Bolt, K. | - |
dc.contributor.author | Sylvain, N. | - |
dc.contributor.author | Maley, S. | - |
dc.contributor.author | Urroz, L. | - |
dc.contributor.author | Kelly, P. J. | - |
dc.contributor.author | Liu, A. | - |
dc.contributor.author | Peeling, L. | - |
dc.contributor.author | Campbell, B. C. V. | - |
dc.contributor.author | Kelly, M. | - |
dc.contributor.author | Whelan, R. | - |
dc.contributor.author | Cooley, R. | - |
dc.contributor.author | Teitelbaum, J. | - |
dc.contributor.author | Boutayeb, A. | - |
dc.contributor.author | Moore, A. | - |
dc.contributor.author | Cole, E. | - |
dc.contributor.author | Waxman, L. | - |
dc.contributor.author | Liddy, A. M. | - |
dc.contributor.author | Ben-Amor, N. | - |
dc.contributor.author | Kennedy, J. | - |
dc.contributor.author | Boyko, M. | - |
dc.contributor.author | Sanchez, R. | - |
dc.contributor.author | Khalil, S. | - |
dc.contributor.author | Nehme, A. | - |
dc.contributor.author | Legault, C. | - |
dc.contributor.author | Tampieri, D. | - |
dc.contributor.author | Ehrensperger, E. | - |
dc.contributor.author | Vieira, L. | - |
dc.contributor.author | Ghoari, B. | - |
dc.contributor.author | Cortes, M. | - |
dc.contributor.author | Angle, M. | - |
dc.contributor.author | Hannouche, M. | - |
dc.contributor.author | Almekhlafi, M. A. | - |
dc.contributor.author | Kenney, C. | - |
dc.contributor.author | Badawy, M. | - |
dc.contributor.author | Werner, K. | - |
dc.contributor.author | Wieszmuellner, S. | - |
dc.contributor.author | Langer, A. | - |
dc.contributor.author | Gisold, A. | - |
dc.contributor.author | Hawkes, C. | - |
dc.contributor.author | Zach, H. | - |
dc.contributor.author | Rommer, P. | - |
dc.contributor.author | Macher, S. | - |
dc.contributor.author | Blechinger, S. | - |
dc.contributor.author | Newcommon, N. | - |
dc.contributor.author | Marik, W. | - |
dc.contributor.author | Kleinig, T. J. | - |
dc.contributor.author | Series, W. | - |
dc.contributor.author | Baumgartinger, M. | - |
dc.contributor.author | Krebs, S. | - |
dc.contributor.author | Enriquez, C. A. | - |
dc.contributor.author | Koski, J. | - |
dc.contributor.author | Eirola, S. | - |
dc.contributor.author | Ivanoff, T. | - |
dc.contributor.author | Erakanto, A. | - |
dc.contributor.author | Kupari, L. | - |
dc.contributor.author | Maraj, N. | - |
dc.contributor.author | Sibolt, G. | - |
dc.contributor.author | Panula, J. | - |
dc.contributor.author | Krishnan, K. | - |
dc.contributor.author | Tomppo, L. | - |
dc.contributor.author | Gladstone, D. J. | - |
dc.contributor.author | Tiainen, M. | - |
dc.contributor.author | Ahlstrom, M. | - |
dc.contributor.author | Martinez Majander, N. | - |
dc.contributor.author | Suomalainen, O. | - |
dc.contributor.author | Raty, S. | - |
dc.contributor.author | Levi, C. | - |
dc.contributor.author | Volny, O. | - |
dc.contributor.author | Kerr, E. | - |
dc.contributor.author | Allen, J. | - |
dc.contributor.author | Kaauwai, L. P. | - |
dc.contributor.author | Manosalva Alzate, H. A. | - |
dc.contributor.author | Lima, F. | - |
dc.contributor.author | Belevski, L. | - |
dc.contributor.author | Russell, M. | - |
dc.contributor.author | Ormond, S. | - |
dc.contributor.author | Chew, A. | - |
dc.contributor.author | Loiselle, A. | - |
dc.contributor.author | Royan, A. | - |
dc.contributor.author | Stys, P. | - |
dc.contributor.author | Hughes, B. | - |
dc.contributor.author | Garcia Esperon, C. | - |
dc.contributor.author | Field, T. S. | - |
dc.contributor.author | Pepper, E. | - |
dc.contributor.author | Miteff, F. | - |
dc.contributor.author | Mandzia, J. L. | - |
dc.contributor.author | He, J. | - |
dc.contributor.author | Lycett, M. | - |
dc.contributor.author | Min, M. | - |
dc.contributor.author | Murray, N. | - |
dc.contributor.author | Pavey, N. | - |
dc.contributor.author | Couillard, P. | - |
dc.contributor.author | Starling de Barros, R. | - |
dc.contributor.author | Sebastian, I. A. | - |
dc.contributor.author | Gangadharan, S. | - |
dc.contributor.author | Dunkerton, S. | - |
dc.contributor.author | Waller, S. | - |
dc.contributor.author | Canento Sanchez, T. | - |
dc.contributor.author | Marko, M. | - |
dc.contributor.author | Wellings, T. | - |
dc.contributor.author | Edmonds, G. | - |
dc.contributor.author | Whittaker, K. A. | - |
dc.contributor.author | Ewing, M. | - |
dc.contributor.author | Ojha, P. | - |
dc.contributor.author | Khosravani, H. | - |
dc.contributor.author | Lee, P. | - |
dc.contributor.author | Singkang, R. | - |
dc.contributor.author | McDonald, A. | - |
dc.contributor.author | Dos Santos, A. | - |
dc.contributor.author | Shin, C. | - |
dc.contributor.author | Jackson, D. | - |
dc.contributor.author | Martins, S. O. | - |
dc.contributor.author | Tsoleridis, J. | - |
dc.contributor.author | Fisicchia, L. | - |
dc.contributor.author | Parsons, N. | - |
dc.contributor.author | Hopyan, J. J. | - |
dc.contributor.author | Eswaradass, P. | - |
dc.contributor.author | Shenoy, N. | - |
dc.contributor.author | Smith, S. | - |
dc.contributor.author | Sharobeam, A. | - |
dc.contributor.author | Balabanski, A. | - |
dc.contributor.author | Park, A. | - |
dc.contributor.author | Williams, C. | - |
dc.contributor.author | Pavlin-Premri, D. | - |
dc.contributor.author | Medvedev, G. | - |
dc.contributor.author | Rodrigues, E. | - |
dc.contributor.author | Sivakumar, K. | - |
dc.contributor.author | Alemseged, F. | - |
dc.contributor.author | Joundi, R. | - |
dc.contributor.author | Ng, F. | - |
dc.contributor.author | Zhao, H. | - |
dc.contributor.author | Beharry, J. | - |
dc.contributor.author | Ng, J. L. | - |
dc.contributor.author | Williamson, J. | - |
dc.contributor.author | Wong, J. Z. W. | - |
dc.contributor.author | Li, K. | - |
dc.contributor.author | Kwan, M. K. | - |
dc.contributor.author | Son, M. | - |
dc.contributor.author | Menon, B. K. | - |
dc.contributor.author | Valente, M. | - |
dc.contributor.author | Casaubon, L. K. | - |
dc.contributor.author | Yassi, N. | - |
dc.contributor.author | Yogendrakumar, V. | - |
dc.contributor.author | McNamara, B. | - |
dc.contributor.author | Buchanan, C. | - |
dc.contributor.author | McCarthy, C. | - |
dc.contributor.author | Thomas, G. | - |
dc.contributor.author | Stephens, K. | - |
dc.contributor.author | Boulos, M. I. | - |
dc.contributor.author | Chung, M. | - |
dc.contributor.author | Chung, M. F. | - |
dc.contributor.author | Mishra, S. M. | - |
dc.contributor.author | Singh, R. | - |
dc.contributor.author | Tang, M. | - |
dc.contributor.author | Busch, T. | - |
dc.contributor.author | Frost, T. | - |
dc.contributor.author | Lee, R. | - |
dc.contributor.author | Stuart, N. | - |
dc.contributor.author | Pachani, N. | - |
dc.contributor.author | Hamind, M. A. | - |
dc.contributor.author | Menon, A. | - |
dc.contributor.author | Borojevic, B. | - |
dc.contributor.author | Linton, C. M. | - |
dc.contributor.author | Garcia, G. | - |
dc.contributor.author | Asuncion, R. M. | - |
dc.contributor.author | Molina, C. | - |
dc.contributor.author | Callaly, E. P. | - |
dc.contributor.author | Dewey, H. | - |
dc.contributor.author | Liu, J. | - |
dc.contributor.author | Chen, J. | - |
dc.contributor.author | Swartz, R. H. | - |
dc.contributor.author | Wong, J. | - |
dc.contributor.author | Nowak, K. | - |
dc.contributor.author | To, K. | - |
dc.contributor.author | Lizak, N. S. | - |
dc.contributor.author | Bhalala, O. | - |
dc.contributor.author | Muir, R. T. | - |
dc.contributor.author | Park, P. | - |
dc.contributor.author | Moussaddy, A. | - |
dc.contributor.author | Tan, P. | - |
dc.contributor.author | Martins, R. | - |
dc.contributor.author | Murphy, R. | - |
dc.contributor.author | Cody, R. | - |
dc.contributor.author | Forbes, R. | - |
dc.contributor.author | Chen, S. K. | - |
dc.contributor.author | Ooi, S. | - |
dc.contributor.author | Tu, S. | - |
dc.contributor.author | Dang, Y. L. | - |
dc.contributor.author | Dey, S. | - |
dc.contributor.author | Ling, Z. | - |
dc.contributor.author | Cranefield, J. | - |
dc.contributor.author | Muir, K. W. | - |
dc.contributor.author | Reiter, S. | - |
dc.contributor.author | Drew, R. | - |
dc.contributor.author | Tan, A. | - |
dc.contributor.author | Kurunawai, C. | - |
dc.contributor.author | Harvey, J. | - |
dc.contributor.author | Mahadevan, J. J. | - |
dc.contributor.author | Cagi, L. | - |
dc.contributor.author | Palanikumar, L. | - |
dc.contributor.author | Mansoor, S. | - |
dc.contributor.author | Chia, L. N. | - |
dc.contributor.author | Goh, R. | - |
dc.contributor.author | Fitzpatrick, T. | - |
dc.contributor.author | El-Masri, S. | - |
dc.contributor.author | Parsons, M. W. | - |
dc.contributor.author | Urbi, B. | - |
dc.contributor.author | Rapier, C. | - |
dc.contributor.author | Berrill, H. | - |
dc.contributor.author | McEvoy, H. | - |
dc.contributor.author | Dunning, R. | - |
dc.contributor.author | Kuriakose, S. | - |
dc.contributor.author | Wasyliw, S. | - |
dc.contributor.author | Chad, T. | - |
dc.contributor.author | Evans, J. | - |
dc.contributor.author | Sapaen, V. | - |
dc.contributor.author | Sabet, A. | - |
dc.contributor.author | Shah, D. | - |
dc.contributor.author | Penn, A. M. W. | - |
dc.contributor.author | Yeow, D. | - |
dc.contributor.author | Lilley, K. | - |
dc.contributor.author | Ward, K. | - |
dc.contributor.author | Mozhy Mahizhnan, M. | - |
dc.contributor.author | Tan, M. | - |
dc.contributor.author | Nagendra, S. | - |
dc.contributor.author | Ganesh, A. | - |
dc.contributor.author | Lynch, C. | - |
dc.contributor.author | Coveney, S. | - |
dc.contributor.author | Tobin, K. | - |
dc.contributor.author | McCabe, J. | - |
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dc.contributor.author | Murphy, S. | - |
dc.contributor.author | Large, M. | - |
dc.contributor.author | Moynihan, B. | - |
dc.contributor.author | Boyle, K. | - |
dc.contributor.author | Bhandari, V. | - |
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dc.contributor.author | Sala, V. | - |
dc.contributor.author | Garcia, L. | - |
dc.contributor.author | Pontes-Neto, O. M. | - |
dc.contributor.author | Garcia-Tornel, A. | - |
dc.contributor.author | Juega, J. | - |
dc.contributor.author | Good, J. | - |
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dc.contributor.author | Olive, M. | - |
dc.contributor.author | Lozano, P. J. | - |
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dc.contributor.author | Deck, M. | - |
dc.contributor.author | Roffe, C. | - |
dc.contributor.author | Penn, M. | - |
dc.contributor.author | Rodriguez, N. | - |
dc.contributor.author | Gomez, B. | - |
dc.contributor.author | Chen, S. | - |
dc.contributor.author | Reyes Munoz, F. J. | - |
dc.contributor.author | Gomez, A. S. | - |
dc.contributor.author | Sanz, A. C. | - |
dc.contributor.author | Garcia, E. C. | - |
dc.contributor.author | Penacoba, G. | - |
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dc.contributor.author | de Lera Alfonso, M. | - |
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dc.contributor.author | Roberts, D. | - |
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dc.contributor.author | Taylor, E. | - |
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dc.contributor.author | El-Masry, A. | - |
dc.contributor.author | O'Hare, C. | - |
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dc.date.accessioned | 2024-09-02T05:57:16Z | - |
dc.date.available | 2024-09-02T05:57:16Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 01406736 (ISSN) | - |
dc.identifier.uri | https://swslhd.intersearch.com.au/swslhdjspui/handle/1/13006 | - |
dc.description.abstract | Background: Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality. Methods: In this multicentre, prospective, parallel group, open label with blinded outcome assessment, randomised controlled trial, adult patients (aged ≥18 years) were included at 48 hospitals in Australia, Austria, Brazil, Canada, Finland, Ireland, New Zealand, Singapore, Spain, and the UK. Eligible patients with minor acute ischaemic stroke (National Institutes of Health Stroke Scale score 0-5) and intracranial occlusion or focal perfusion abnormality were enrolled within 12 h from stroke onset. Participants were randomly assigned (1:1), using a minimal sufficient balance algorithm to intravenous tenecteplase (0·25 mg/kg) or non-thrombolytic standard of care (control). Primary outcome was a return to baseline functioning on pre-morbid modified Rankin Scale score in the intention-to-treat (ITT) population (all patients randomly assigned to a treatment group and who did not withdraw consent to participate) assessed at 90 days. Safety outcomes were reported in the ITT population and included symptomatic intracranial haemorrhage and death. This trial is registered with ClinicalTrials.gov, NCT02398656, and is closed to accrual. Findings: The trial was stopped early for futility. Between April 27, 2015, and Jan 19, 2024, 886 patients were enrolled; 369 (42%) were female and 517 (58%) were male. 454 (51%) were assigned to control and 432 (49%) to intravenous tenecteplase. The primary outcome occurred in 338 (75%) of 452 patients in the control group and 309 (72%) of 432 in the tenecteplase group (risk ratio [RR] 0·96, 95% CI 0·88-1·04, p=0·29). More patients died in the tenecteplase group (20 deaths [5%]) than in the control group (five deaths [1%]; adjusted hazard ratio 3·8; 95% CI 1·4-10·2, p=0·0085). There were eight (2%) symptomatic intracranial haemorrhages in the tenecteplase group versus two (<1%) in the control group (RR 4·2; 95% CI 0·9-19·7, p=0·059). Interpretation: There was no benefit and possible harm from treatment with intravenous tenecteplase. Patients with minor stroke and intracranial occlusion should not be routinely treated with intravenous thrombolysis. Funding: Heart and Stroke Foundation of Canada, Canadian Institutes of Health Research, and the British Heart Foundation. � 2024 Elsevier Ltd | - |
dc.publisher | Elsevier B.V. | - |
dc.subject | Aged Female Fibrinolytic Agents Humans Ischemic Stroke Male Middle Aged Prospective Studies Standard of Care Tenecteplase Thrombolytic Therapy Tissue Plasminogen Activator Treatment Outcome fibrinolytic agent clinical trial controlled study drug therapy fibrinolytic therapy health care quality human multicenter study phase 3 clinical trial procedures prospective study randomized controlled trial | - |
dc.title | Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial | - |
dc.type | Journal Article | - |
dc.contributor.swslhdauthor | Parsons, Mark W. | - |
dc.description.affiliates | Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada the O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Department of Neurology, King's College Hospital London, United Kingdom Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada Stroke Program, Department of Neurology, Hospital Cl�nico Universitario, Valladolid, Spain Valladolid Health Research Institute, Department of Medicine, University of Valladolid, Valladolid, Spain Department of Imaging, Foothills Medical Centre, Calgary, AB, Canada Alberta Children's Hospital, Calgary, AB, Canada Griffith University, Gold Coast, QLD, Australia Botucatu Medical School, S�o Paulo State University, San Paulo, Brazil Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada School of Clinical Medicine, University of New South Wales, NSW, Australia CHU de Qu�bec?H�pital de l'Enfant-J�sus, Quebec City, QC, Canada Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia University Health Network?Toronto Western Hospital, University of Toronto, Toronto, ON, Canada Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada McMaster University, Population Health Research Institute, Hamilton, ON, Canada Countess of Chester Hospital NHS Foundation Trust, Chester, United Kingdom Department of Neuroscience, Box Hill Hospital, Eastern Health, Melbourne, VIC, Australia Eastern Health Clinical School, Monash University, Melbourne, VIC, Australia St George's University Hospitals, London, United Kingdom Department of Medicine, University of Ottawa, Ottawa, ON, Canada Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, ON, Canada Department of Neurology, St John's of God Hospital Vienna, Vienna, Austria Vancouver Stroke Program, Division of Neurology, University of British Columbia, Vancouver, BC, Canada Royal Columbian Hospital, University of British Columbia, Vancouver, BC, Canada Fiona Stanley Hospital, Murdoch, Western Australia, University of Western Australia, Perth, WA, Australia Department of Neurology, Medical University of Vienna, Vienna, Austria Imperial College Healthcare Trust, London, United Kingdom University of Saskatchewan, Saskatoon, SK, Canada Red Deer Regional Hospital Centre, Red Deer, AB, Canada School of Medicine University College Dublin?Mater University Hospital Dublin, Dublin, Ireland Acute Multidisciplinary Imaging and Interventional Centre, John Radcliffe Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom Department of Neurology, Royal Adelaide Hospital, Adelaide, SA, Australia Department of Medicine, University of Adelaide, Adelaide, SA, Australia Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom Hospital Geral De Fortaleza, Fortaleza, Brazil Department of Clinical Neurological Sciences, Western University, London, ON, Canada Hospital de Cl�nicas de Porto Alegre, Hospital Moinhos de Vento, Porto Alegre, Brazil Neurology Department, Hospital Moinhos de Vento, Porto Alegre, Brazil Vall d'Hebron Stroke Center, Hospital Vall d'Hebron, Barcelona, Spain Montreal Neurological Institute, McGill University Health Centre, Montreal, QC, Canada School of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom Department of Neurology, Liverpool Hospital, UNSW South West Sydney, Sydney, NSW, Australia Victoria General Hospital, Victoria, BC, Canada Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil Stroke Research, Keele University, Stoke-on-Trent, United Kingdom Stroke Unit, Neurology Department, Hospital Trueta de Girona, Fundaci� Institut d'Investigaci� Biom�dica de Girona Dr Josep Trueta, Girona, Spain University College Hospitals London, London, United Kingdom Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia Heart and Stroke Program, Hunter Medical Research Institute, Newcastle, NSW, Australia Department of Neurology, John Hunter Hospital, Newcastle, NSW, Australia Department of Neurology, Helsinki University Hospital and University ofHelsinki, Helsinki, Finland National Neuroscience Institute, Singapore Royal Victoria Hospital, Belfast, United Kingdom RCSI University of Medicine and Health Sciences and Beaumont Hospital, Dublin, Ireland University Hospitals Birmingham NHS Trust, Birmingham, United Kingdom Department of Neurology, Christchurch Hospital, Christchurch, New Zealand Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom Unity Health Toronto, St Michael's Hospital, Toronto, ON, Canada St�dtisches Klinikum Dresden, Dresden, Germany | - |
dc.identifier.doi | 10.1016/S0140-6736(24)00921-8 | - |
dc.identifier.department | Liverpool Hospital, Department of Neurology and Neurophysiology | - |
dc.type.studyortrial | Article | - |
dc.identifier.journaltitle | The Lancet | - |
Appears in Collections: | Liverpool Hospital |
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