Please use this identifier to cite or link to this item: https://swslhd.intersearch.com.au/swslhdjspui/handle/1/13114
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dc.contributor.authorSinha, A.-
dc.contributor.authorGupta, M.-
dc.contributor.authorBhaskar, S. M. M.-
dc.date.accessioned2024-12-11T00:34:12Z-
dc.date.available2024-12-11T00:34:12Z-
dc.date.issued2024-
dc.identifier.issn0953816X (ISSN)-
dc.identifier.urihttps://swslhd.intersearch.com.au/swslhdjspui/handle/1/13114-
dc.description.abstractLeptomeningeal collaterals (LMCs) are crucial in mitigating the impact of acute ischemic stroke (AIS) by providing alternate blood flow routes when primary arteries are obstructed. This article explores the evolutionary pathophysiology of LMCs, highlighting their critical function in stroke and the genetic and molecular mechanisms governing their development and remodelling. We address the translational challenges of applying animal model findings to human clinical scenarios, emphasizing the need for further research to validate emerging therapies?such as pharmacological agents, gene therapy and mechanical interventions?in clinical settings, aimed at enhancing collateral perfusion. Computational modelling emerges as a promising method for integrating experimental data, which requires precise parameterization and empirical validation. We introduce the ?Evolucollateral Dynamics? hypothesis, proposing a novel framework that incorporates evolutionary biology principles into therapeutic strategies, offering new perspectives on enhancing collateral circulation. This hypothesis emphasizes the role of genetic predispositions and environmental influences on collateral circulation, which may impact therapeutic strategies and optimize treatment outcomes. Future research must incorporate human clinical data to create robust treatment protocols, thereby maximizing the therapeutic potential of LMCs and improving outcomes for stroke patients. � 2024 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.-
dc.publisherJohn Wiley and Sons Inc-
dc.subjectacute ischaemic stroke clinical decision making collaterals reperfusion reperfusion therapy animal model blood flow cerebrovascular accident collateral circulation computer model evolutionary biology gene therapy genetic predisposition human nonhuman pathophysiology pharmacology review stroke patient therapy treatment outcome treatment protocol-
dc.titleEvolucollateral dynamics in stroke: Evolutionary pathophysiology, remodelling and emerging therapeutic strategies-
dc.typeJournal Article-
dc.description.affiliatesGlobal Health Neurology Lab, Sydney, NSW, Australia UNSW Medicine and Health, University of New South Wales (UNSW), South West Sydney Clinical Campuses, Sydney, NSW, Australia NSW Brain Clot Bank, NSW Health Pathology, Sydney, NSW, Australia Department of Neurology & Neurophysiology, Liverpool Hospital and South West Sydney Local Health District, Liverpool, NSW, Australia Clinical Sciences Stream, Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia Department of Neurology, Division of Cerebrovascular Medicine and Neurology, National Cerebral and Cardiovascular Center (NCVC), Osaka, Suita, Japan-
dc.identifier.doi10.1111/ejn.16585-
dc.type.studyortrialReview-
dc.identifier.journaltitleEuropean Journal of Neuroscience-
Appears in Collections:South Western Sydney Local Health District

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