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Title: | Postpartum dysglycaemia after early gestational diabetes: Follow-up of women in the TOBOGM randomised controlled trial |
Authors: | Cheung, N. W. Rhou, Y. J. J. Immanuel, J. Hague, W. M. Teede, H. Nolan, C. J. Peek, M. J. Flack, J. R. McLean, M. Wong, V. W. Hibbert, E. J. Kautzky-Willer, A. Harreiter, J. Backman, H. Gianatti, E. Sweeting, A. Mohan, V. Simmons, D. |
SWSLHD Author: | Flack, Jeffrey R. |
Affiliates: | Westmead Hospital, Westmead, NSW, Australia University of Sydney, Sydney, NSW, Australia Western Sydney University, Campbelltown, NSW, Australia Robinson Research Institute, The University of Adelaide, SA, Australia Monash University, Melbourne, VIC, Australia Canberra Health Services, Canberra, Australia Australian National University, Canberra, Australia Nepean Hospital, Sydney, NSW, Australia Bankstown-Lidcombe Hospital, Sydney, Australia Blacktown Hospital, Sydney, Australia Liverpool Hospital, Sydney and University of New South Wales, NSW, Australia Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Australia Department of Medicine, Landesklinikum Scheibbs, Australia Dept of Obstetrics and Gynecology, Faculty of Medicine and Health, �rebro University, Sweden Department of Endocrinology, Fiona Stanley Hospital, Murdoch, WA, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia Dr. Mohan's Diabetes Specialities Centre and Madras Diabetes Research Foundation, Chennai, India |
Department: | Bankstown-Lidcombe Hospital, Department of Diabetes & Endocrinology |
Issue Date: | 2024 |
Journal: | Diabetes Research and Clinical Practice |
Publisher: | Elsevier Ireland Ltd |
Abstract: | Aim: To evaluate the incidence and predictors of postpartum dysglycaemia among high-risk women who develop early gestational diabetes (eGDM) prior to 20 weeks? gestation. Methods: This is a sub-study of the Treatment of Booking Gestational Diabetes (TOBOGM) Study, a randomised controlled trial of early or deferred treatment for women with risk factors for gestational diabetes diagnosed with eGDM, using current WHO criteria. Overt diabetes in pregnancy was excluded. A repeat oral glucose tolerance test (oGTT) was recommended at 6?12 weeks postpartum. Results: Of 793 participants, 352 (44.4%) underwent a postpartum oGTT. Baseline characteristics of participants with and without an oGTT were similar. Ninety-two (26.1%) had postpartum dysglycaemia: 11 (3.1%) diabetes, 31 (8.8%) impaired fasting glucose (IFG), 39 (11.1%) impaired glucose tolerance (IGT), and 11 (3.1%) combined IFG/IGT. Participants with postpartum dysglycaemia were more likely to have had past GDM, lower body mass index, more gestational weight gain, and higher 1 and 2-hour glucose concentrations on the early pregnancy oGTT. On logistic regression, higher 1 and 2-hour glucose concentration, previous GDM and greater gestational weight gain were independently associated with postpartum dysglycaemia. Conclusion: There is a high incidence of postpartum dysglycaemia among high-risk women with eGDM. � 2024 |
URI: | https://swslhd.intersearch.com.au/swslhdjspui/handle/1/13170 |
ISSN: | 01688227 (ISSN) |
Digital object identifier: | 10.1016/j.diabres.2024.111929 |
Appears in Collections: | Bankstown-Lidcombe Hospital Liverpool Hospital |
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