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https://swslhd.intersearch.com.au/swslhdjspui/handle/1/12473| Title: | Involvement of single nucleotide polymorphisms of junction adhesion molecule with small vessel vascular dementia |
| Authors: | Xie, P. Kancherla, K. Chandramohan, S. Braidy, N. Chan, E. K. W. Xu, Y. H. Chan, D. K. Y. |
| SWSLHD Author: | Xu, Ying H. Chan, Daniel K. |
| Affiliates: | Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia Ingham Institute, Liverpool, NSW, Australia Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia Faculty of Medicine, Western Sydney University, Macarthur, NSW, Australia Department of Aged Care and Rehabilitation, Bankstown Hospital, Bankstown, NSW, Australia |
| Department: | Bankstown-Lidcombe Hospital, Department of Aged Care & Rehabilitation |
| Issue Date: | 2023 |
| Journal: | Aging Medicine |
| Publisher: | John Wiley and Sons Inc |
| Abstract: | Objectives: It is now recognized that blood brain barrier (BBB) leakage occurs in cerebral small vascular disease (CSVD) and plays a significant role in the pathophysiology of vascular dementia. We hypothesized that genetic polymorphisms of junctional adhesion molecule-A (JAM-A) (which may result in compromised structure of tight junction proteins that form the BBB) in combination with cerebrovascular risk factors hypertension, lipid disorders, and type 2 diabetes may result in BBB leakage and increase the individual's risk of CSVD-related dementia. Methods: In this case-control study, 97 controls with a mean Mini-Mental State Exam (MMSE) score of 29 and 38 CSVD-related vascular dementia participants (mean MMSE score of 19) were recruited. Bloods were collected for the analysis of two common single nucleotide polymorphisms (SNPs) of the JAM-A genotypes rs790056 and rs2481084 using real-time polymerase chain reaction (PCR) assay. Medical history of hypertension, hyperlipidemia, and diabetes was collected for all participants. Results: Polymorphisms of genotype JAM-A SNP rs790056 showed statistically significant result when the subgroup with hyperlipidemia was analyzed (OR = 3.130, p = 0.042 for TC + CC genotypes with hyperlipidaemia vs controls). Similar result was found with diabetes (OR = 4.670, p = 0.031 for TC + CC genotypes vs controls). No significant result was found with hypertension. Borderline results of statistical significance were found for JAM-A SNP rs2481084 with hyperlipidemia (OR = 3.210, p = 0.054 for TC + CC genotypes vs controls) and with diabetes (OR = 3.620, p = 0.069 for TC + CC genotypes vs controls) but not for hypertension. The borderline results might have been due to lack of statistical power because of small sample size. Conclusions: These results lend further support that cerebrovascular risk factors interact with genetic polymorphisms of BBB proteins to increase the risk of vascular dementia. |
| URI: | https://swslhd.intersearch.com.au/swslhdjspui/handle/1/12473 |
| ISSN: | 24750360 (ISSN) |
| Digital object identifier: | 10.1002/agm2.12278 |
| Appears in Collections: | Bankstown-Lidcombe Hospital |
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